Reagan is a Bioinformatics PhD student in the Kardia lab. He is developing novel ways of integrating clinical and genetic information to improve chronic disease risk prediction. He also studies the effect of genetic polymorphisms on the development and progression of heart failure.

His other research interests include the visualization of high-dimensional genetic association data, cancer biology and risk prediction, and the role ofredox state in cell differentiation. He blogs about personalized medicine at his site http://www.reagank.com

Selected Publications:

Liggett SB*, Cresci S*, Kelly RJ*, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW 2nd. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat Med. 2008 May;14(5):510-7.

Liggett SB*, Kelly RJ*, Parekh RR, Matkovich SJ, Benner BJ, Hahn HS, Syed FM, Galvez AS, Case KL, McGuire N, Odley AM, Sparks L, Kardia SL, Dorn GW. A Functional Polymorphism of the Gq (GNAQ) Gene is Associated with Accelerated Mortality in African American Heart Failure. Hum Mol Genet. 2007 Nov 15;16(22):2740-50.

Kelly RJ, Jacobsen DM, Sun YV, Smith JA, Kardia SLR. KGraph: A System for Visualizing and Evaluating Complex Genetic Associations. Bioinformatics 2007 Jan 15; 23(2):249-51. doi: 10.1093/bioinformatics/btl510.